Instance ID10619
Regular Expression((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx
Motif InstanceQLRIDSFFRL
Bait Uniprot AccessionP28715
Bait Uniprot IdentifierERCC5_HUMAN
Bait Gene NameERCC5
Bait OrganismHomo sapiens (Human)
Sequence Position990-999
Critical ResiduesP3
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Site-directed mutagenesis; Competition binding assay; Pull down(GST tag)
Interaction ID20619
Interacting DomainPCNA, C-terminal domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9305916
CommentsThe PCNA binding PIP box motif in human DNA excision repair protein ERCC-5, a structure-specific endonuclease involved in DNA replication, that mediates its interaction with Proliferating cell nuclear antigen (PCNA)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)