Instance ID10624
Regular Expression((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx
Motif InstanceQGRLDDFFKV
Bait Uniprot AccessionP39748
Bait Uniprot IdentifierFEN1_HUMAN
Bait Gene NameFEN1
Bait OrganismHomo sapiens (Human)
Sequence Position337-346
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)X-ray crystallography; Peptide mapping; Y2H; Co-IP; Competition binding assay
Interaction ID20624
Interacting DomainPCNA, C-terminal domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15576034, 9178907
CommentsThe PCNA binding PIP box motif in human Flap endonuclease 1 (FEN1)/ DNase IV that mediates interaction with human Proliferating cell nuclear antigen (PCNA/Cyclin)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)