Instance ID10639
Regular Expressionxxx[ST]x[ACVILF]$
Motif InstanceRRESAI
Bait Uniprot AccessionP48050
Bait Uniprot IdentifierKCNJ4_HUMAN
Bait Gene NameKCNJ4
Bait OrganismHomo sapiens (Human)
Sequence Position440-445
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Ser-P4
Secondary StructureDisordered
Experimental Method(s)Pull down; ITC; Mutation analysis; X-ray crystallography
Interaction ID20639
Interacting DomainPDZ domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)19635485
CommentsC-terminal class 1 PDZ-binding motif in human Inward rectifier K(+) channel Kir2.3 protein (KCNJ4) that mediates binding to the human Tax1-binding protein 3 (TAX1BP3)/ Tax-interacting protein 1 (TIP1)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)