Instance ID10656
Regular Expressionxxx[ST]x[ACVILF]$
Motif InstanceVQDTRL
Bait Uniprot AccessionP13569
Bait Uniprot IdentifierCFTR_HUMAN
Bait Gene NameCFTR
Bait OrganismHomo sapiens (Human)
Sequence Position1475-1480
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)X-ray crystallography; Far Western blotting; SPR; Pull down; Mutation analysis; Western blot
Interaction ID20656
Interacting DomainPDZ domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11304524, 9677412
CommentsC-terminal PDZ domain-binding motif in human Cystic fibrosis transmembrane conductance regulator (CFTR) that mediates binding to the first PDZ domain of the Na+/H+ exchanger regulatory factor (NHERF/EBP50)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)