Instance ID10657
Regular Expressionxxx[ST]x[ACVILF]$
Motif InstanceSFLTWL
Bait Uniprot AccessionP46937
Bait Uniprot IdentifierYAP1_HUMAN
Bait Gene NameYAP1
Bait OrganismHomo sapiens (Human)
Sequence Position499-504
Critical ResiduesP3; P4; P5; P6
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Mutation disrupting interaction; Peptide binding to perpetrator; Pull down; Co-IP; Colocalization; Competition binding; Mutation analysis
Interaction ID20657
Interacting DomainPDZ domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10562288
CommentsC-terminal class 1 PDZ-binding motif (499-504) in human Cystic fibrosis transmembrane conductance regulator (CFTR) that mediates binding to the PDZ domain of Na(+)/H(+) exchange regulatory cofactor NHERF1/EBP50 (SLC9A3R1)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)