Instance ID10660
Regular Expressionxxx[ST]x[ACVILF]$
Motif InstanceRRETQV
Bait Uniprot AccessionP06463
Bait Uniprot IdentifierVE6_HPV18
Bait Gene NameE6
Bait OrganismHuman papillomavirus type 18
Sequence Position153-158
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)X-ray crystallography; ITC; NMR
Interaction ID20660
Interacting DomainPDZ domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)17267502, 17713926
CommentsC terminal binding motif of E6 oncoprotein of Human papillomavirus type 18 that binds to all three PDZ domains of DLG and causes a dramatic reduction in the levels of DLG expression by targeting it for proteasome mediated degradation

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)