Instance ID10688
Regular Expression[DEN][DEN]x{2,3}[ILMVA][DEN][DEN]L
Motif InstanceEESLADDL
Bait Uniprot AccessionO60934
Bait Uniprot IdentifierNBN_HUMAN
Bait Gene NameNBN
Bait OrganismHomo sapiens (Human)
Sequence Position736-743
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Competition binding; Co-IP; Pull down
Interaction ID20688
Interacting DomainHEAT repeat domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)17507690, 15964794, 15758953
CommentsThe extreme C terminus of human Nibrin/NBS1(NBN) contains an evolutionarily conserved sequence motif that is critical for binding to and activation of Serine-protein kinase ATM in the cellular response to DNA damage induced by ionizing radiation (IR)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)