Instance ID10692
Regular Expressionxx[RK]x{0,1}[VIL][^P][FW]x
Motif InstanceLKKLRFD
Bait Uniprot AccessionP06400
Bait Uniprot IdentifierRB_HUMAN
Bait Gene NameRB1
Bait OrganismHomo sapiens (Human)
Sequence Position872-878
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Phosphatase assay; ITC; Mutation analysis; X-ray crystallography
Interaction ID20692
Interacting DomainCalcineurin-like phosphoesterase domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)20694007
CommentsAn enzyme docking site in the human Retinoblastoma-associated protein (RB1/Rb) C-terminal domain that is required for association of Rb with the catalytic subunit of protein phosphatase 1 (PP1c) and efficient PP1c activity toward Rb

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)