Instance ID10705
Regular Expressionxx[RK]x{0,1}[VIL][^P][FW]x
Motif InstanceSPKVTFE
Bait Uniprot AccessionP38398
Bait Uniprot IdentifierBRCA1_HUMAN
Bait Gene NameBRCA1
Bait OrganismHomo sapiens (Human)
Sequence Position896-902
Critical ResiduesP6
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Co-IP; Pull down; Mutation analysis; Western blot
Interaction ID20705
Interacting DomainCalcineurin-like phosphoesterase domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)17603999
CommentsThe catalytic subunit of human protein phosphatase 1 (PPP1CA) interacts with and dephosphorylates human Breast cancer type 1 susceptibility protein (BRCA1) through the RVXF motif of BRCA1 and may thus serve as a general regulator for BRCA1 phosphorylation

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)