Instance ID10708
Regular Expressionxx[RK]x{0,1}[VIL][^P][FW]x
Motif InstanceSPKGVLFS
Bait Uniprot AccessionQ92667
Bait Uniprot IdentifierAKAP1_HUMAN
Bait Gene NameAKAP1
Bait OrganismHomo sapiens (Human)
Sequence Position151-158
Critical ResiduesP5
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Affinity chromatography technology; Far Western blotting; Co-IP; Competition binding; Mutation analysis
Interaction ID20708
Interacting DomainCalcineurin-like phosphoesterase domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10995432
CommentsThe RVXF motif of human A-kinase anchoring protein AKAP149 (AKAP1) that mediates binding to the catalytic subunit of protein phosphatase 1 (PPP1CA) whereby AKAP149 recruits PP1 at the nuclear envelope (NE) upon somatic nuclear reformation, a prerequisite for assembly of B-type lamins

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)