Instance ID10722
Regular ExpressionxP[TS]APx
Motif InstanceIPSAPL
Bait Uniprot AccessionO60291
Bait Uniprot IdentifierMGRN1_HUMAN
Bait Gene NameMGRN1
Bait OrganismHomo sapiens (Human)
Sequence Position405-410
Critical ResiduesP2; P5
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Pull down; Co-IP; Classical fluorescence spectroscopy; Y2H
Interaction ID20722
Interacting DomainUEV domain
Disease Association(s)Spongiform Neurodegeneration
Inhibitor(s)Unknown
Reference(s)17229889
CommentsSpongiform neurodegeneration-associated E3 ubiquitin-protein ligase Mahogunin (MGRN1) ubiquitylates human Tumor susceptibility gene 101 protein (TSG101) and thereby regulates endosomal trafficking

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)