Instance ID10735
Regular Expression(x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x)
Motif InstanceGYENPTYK
Bait Uniprot AccessionP05067
Bait Uniprot IdentifierA4_HUMAN
Bait Gene NameAPP
Bait OrganismHomo sapiens (Human)
Sequence Position756-763
Critical ResiduesP2; P3
Motif PTM(s)Phosphorylation at Tyr-P7
Secondary StructureBeta turn
Experimental Method(s)Mutation analysis; SPR; X-ray crystallography
Interaction ID20735
Interacting DomainPTB domain
Disease Association(s)Alzheimer's disease; Cerebral amyloid angiopathy
Inhibitor(s)Unknown
Reference(s)10373567, 9321393, 18833287, 8887653
CommentsThe phosphotyrosine-binding domain (PTB) of the human adaptor protein X11alpha/MINT1/APBA1 binds to the the NPxY PTB-binding motif of Human amyloid precursor protein (APP)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)