Instance ID10737
Regular Expression(x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x)
Motif InstanceGYENPTYK
Bait Uniprot AccessionP05067
Bait Uniprot IdentifierA4_HUMAN
Bait Gene NameAPP
Bait OrganismHomo sapiens (Human)
Sequence Position756-763
Critical ResiduesP1; P2; P4; P7
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Mutation analysis; Filter binding assay; Fluorescence anisotropy; Y2H
Interaction ID20737
Interacting DomainPTB domain
Disease Association(s)Alzheimer's disease; Cerebral amyloid angiopathy
Inhibitor(s)Unknown
Reference(s)10373567, 9321393, 18833287, 8887653
CommentsThe amino-terminal phosphotyrosine-binding (PTB) domain of human Disabled homolog 1 (DAB1) binds specifically to the transmembrane glycoproteins of the human amyloid precursor protein (APP) through the NPXY motif but does not bind to tyrosine-phosphorylated peptide ligands


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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)