Instance ID10744
Regular Expression(x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x)
Motif InstanceGYENPTYK
Bait Uniprot AccessionP08592
Bait Uniprot IdentifierA4_RAT
Bait Gene NameApp
Bait OrganismRattus norvegicus (Rat)
Sequence Position756-763
Critical ResiduesP2; P7
Motif PTM(s)Unknown
Secondary StructureBeta turn
Experimental Method(s)X-ray crystallography; Mutation analysis
Interaction ID20744
Interacting DomainPTB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12826668
CommentsInteraction of the phosphotyrosine-binding (PTB) domain of mouse Disabled homolog 1 (Dab1) with the NPXY motif of the rat amyloid precursor protein (App)


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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)