Instance ID10745
Regular Expression(x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x)
Motif InstanceGYENPTYK
Bait Uniprot AccessionP12023
Bait Uniprot IdentifierA4_MOUSE
Bait Gene NameApp
Bait OrganismMus musculus (Mouse)
Sequence Position756-763
Critical ResiduesP2
Motif PTM(s)Unknown
Secondary StructureBeta turn
Experimental Method(s)ITC; Mutation analysis; NMR
Interaction ID20745
Interacting DomainPTB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)18650440
CommentsInteraction of the C-terminal phosphotyrosine-binding (PTB) domain of the mouse adaptor protein Fe65L1/Apbb2 with the NPxY PTB-binding motif of mouse amyloid precursor protein (App)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)