Instance ID10748
Regular Expression(x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x)
Motif InstanceTANNPLYK
Bait Uniprot AccessionP05106
Bait Uniprot IdentifierITB3_HUMAN
Bait Gene NameITGB3
Bait OrganismHomo sapiens (Human)
Sequence Position767-774
Critical ResiduesP4; P7
Motif PTM(s)Unknown
Secondary StructureBeta turn
Experimental Method(s)X-ray crystallography; Mutation analysis; NMR
Interaction ID20748
Interacting DomainPTB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12535520, 18156175
CommentsThe NPxY motif (767-774) in human Integrin beta-1 (ITGB1) that mediates its interaction with the phosphotyrosine-binding (PTB) domain of chicken Talin-1 (TLN1)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)