Instance ID10749
Regular Expression(x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x)
Motif InstanceEIGNPTYK
Bait Uniprot AccessionQ07954
Bait Uniprot IdentifierLRP1_HUMAN
Bait Gene NameLRP1
Bait OrganismHomo sapiens (Human)
Sequence Position4467-4474
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Co-IP; Pull down; Mutation analysis; Knock out
Interaction ID20749
Interacting DomainPTB domain
Disease Association(s)Alzheimer's disease
Inhibitor(s)Unknown
Reference(s)15115822, 16382151
CommentsThe interaction of the phosphotyrosine-binding (PTB) domain of the human adaptor protein FE65/APBB1 with the NPxY motif (4467-4474) of human Apolipoprotein E receptor LRP1 whereby FE65 acts as a functional linker between APP and LRP

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)