Instance ID10754
Regular Expression(x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x)
Motif InstanceGLDNPAYV
Bait Uniprot AccessionQ8TBB1
Bait Uniprot IdentifierLNX1_HUMAN
Bait Gene NameLNX1
Bait OrganismHomo sapiens (Human)
Sequence Position178-185
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Fluorescence polarization spectroscopy; Co-IP; Pull down; Y2H; Competition binding
Interaction ID20754
Interacting DomainPTB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9846878, 9535908
CommentsHigh-affinity binding of the Drosophila Numb phosphotyrosine-binding (PTB) domain to the NPXY motif of human E3 ubiquitin-protein ligase LNX1

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)