Instance ID10757
Regular Expression(x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y))
Motif InstanceLLSNPTY
Bait Uniprot AccessionP03077
Bait Uniprot IdentifierMT_POVMA
Bait Gene NameNot Available
Bait OrganismMurine polyomavirus (strain A2) (MPyV)
Sequence Position244-250
Critical ResiduesP2; P7
Motif PTM(s)Phosphorylation at Tyr-P7
Secondary StructureBeta turn
Experimental Method(s)NMR; Alanine scanning
Interaction ID20757
Interacting DomainPTB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)7543098
CommentsPhosphorylation of Y250 in the PTB-binding NPxY motif of Middle T antigen of Murine polyomavirus induces binding to the PTB domain of human SHC-transforming protein 1 (SHC1)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)