Instance ID10759
Regular Expression(x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y))
Motif InstanceLHPNPMY
Bait Uniprot AccessionQ61006
Bait Uniprot IdentifierMUSK_MOUSE
Bait Gene NameMusk
Bait OrganismMus musculus (Mouse)
Sequence Position547-553
Critical ResiduesP1; P2; P7
Motif PTM(s)Phosphorylation at Tyr-P7
Secondary StructureBeta turn
Experimental Method(s)Protein kinase assay; X-ray crystallography
Interaction ID20759
Interacting DomainPTB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)20603078
CommentsThe mouse cytoplasmic adaptor protein Dok7 activates the mouse Muscle-specific tyrosine-protein kinase receptor Musk via interaction of its phosphotyrosine-binding (PTB) domain with a phosphopeptide motif in Musk

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)