Instance ID10761
Regular Expression(x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y))
Motif InstanceTANNPLY
Bait Uniprot AccessionP05106
Bait Uniprot IdentifierITB3_HUMAN
Bait Gene NameITGB3
Bait OrganismHomo sapiens (Human)
Sequence Position767-773
Critical ResiduesP7
Motif PTM(s)Phosphorylation at Tyr-P7
Secondary StructureBeta turn
Experimental Method(s)NMR; Alanine scanning; SPR
Interaction ID20761
Interacting DomainPTB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)18156175, 20739287, 12606711
CommentsThe phosphotyrosine binding (PTB) domain of human SHC-transforming protein 1 (SHC1) binds to tyrosine-phosphorylated NPxY motif (767-773) of human Integrin beta-3 (ITGB3)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)