Instance ID10764
Regular Expression(x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y))
Motif InstanceIAGNPAY
Bait Uniprot AccessionP24394
Bait Uniprot IdentifierIL4RA_HUMAN
Bait Gene NameIL4R
Bait OrganismHomo sapiens (Human)
Sequence Position491-497
Critical ResiduesP1; P7
Motif PTM(s)Phosphorylation at Tyr-P7
Secondary StructureBeta turn
Experimental Method(s)Mutation analysis; ITC; NMR
Interaction ID20764
Interacting DomainPTB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)8599766
CommentsThe PTB domain of human Insulin receptor substrate 1 (IRS1) can recognize and bind specifically to phosphotyrosine-containing NPxY motif of human Interleukin-4 receptor subunit alpha

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)