Instance ID10766
Regular Expression(x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y))
Motif InstanceWIENKLY
Bait Uniprot AccessionP35546
Bait Uniprot IdentifierRET_MOUSE
Bait Gene NameRet
Bait OrganismMus musculus (Mouse)
Sequence Position1057-1063
Critical ResiduesP1; P6; P7
Motif PTM(s)Phosphorylation at Tyr-P7
Secondary StructureBeta turn
Experimental Method(s)SPR; X-ray crystallography
Interaction ID20766
Interacting DomainPTB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)14607833
CommentsThe N-terminal phosphotyrosine binding (PTB) domain of Mouse Dok1 can recognize and bind specifically to phosphotyrosine-containing NPxY motif of Mouse Proto-oncogene tyrosine-protein kinase receptor Ret

© 2014 Bose Institute, Kolkata. All rights reserved

For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)