Instance ID10767
Regular Expression(x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y))
Motif InstanceCFTNQGY
Bait Uniprot AccessionP14784
Bait Uniprot IdentifierIL2RB_HUMAN
Bait Gene NameIL2RB
Bait OrganismHomo sapiens (Human)
Sequence Position358-364
Critical ResiduesUnknown
Motif PTM(s)Phosphorylation at Tyr-P7
Secondary StructureBeta turn
Experimental Method(s)Co-IP; Mutation analysis; Pull down
Interaction ID20767
Interacting DomainPTB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)8643566
CommentsThe phosphotyrosine-binding (PTB) domain of human SHC-transforming protein 1 (SHC1) interacts with the tyrosine-phosphorylated NPxY motif of human Interleukin-2 receptor subunit beta (IL2RB)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)