Instance ID10768
Regular Expression(x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y))
Motif InstanceLLPNHSY
Bait Uniprot AccessionP16144
Bait Uniprot IdentifierITB4_HUMAN
Bait Gene NameITGB4
Bait OrganismHomo sapiens (Human)
Sequence Position1590-1596
Critical ResiduesP7
Motif PTM(s)Phosphorylation at Tyr-P7
Secondary StructureBeta turn
Experimental Method(s)Co-IP; Mutation analysis; Pull down
Interaction ID20768
Interacting DomainPTB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11044453
CommentsThe phosphotyrosine-binding (PTB) domain of human SHC-transforming protein 1 (SHC1) interacts with the tyrosine-phosphorylated NPxY motif of human Integrin beta-4 (ITGB4)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)