Instance ID10769
Regular Expression(x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y))
Motif InstanceMFENPLY
Bait Uniprot AccessionQ92835
Bait Uniprot IdentifierSHIP1_HUMAN
Bait Gene NameINPP5D
Bait OrganismHomo sapiens (Human)
Sequence Position1016-1022
Critical ResiduesP7
Motif PTM(s)Phosphorylation at Tyr-P7
Secondary StructureBeta turn
Experimental Method(s)Co-IP; Pull down; Protein kinase assay; Mutation analysis
Interaction ID20769
Interacting DomainPTB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9099679
CommentsThe phosphotyrosine binding (PTB) domain of human SHC-transforming protein 1 (SHC1) binds to tyrosine-phosphorylated NPxY motif (1016-1022) of human SH2-containing inositol phosphatase (SHIP/INPP5D)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)