Instance ID10770
Regular Expression(x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y))
Motif InstanceASSNPEY
Bait Uniprot AccessionP06213
Bait Uniprot IdentifierINSR_HUMAN
Bait Gene NameINSR
Bait OrganismHomo sapiens (Human)
Sequence Position993-999
Critical ResiduesP4; P5; P7
Motif PTM(s)Phosphorylation at Tyr-P7
Secondary StructureBeta turn
Experimental Method(s)Protein kinase assay; Y2H; Alanine scanning
Interaction ID20770
Interacting DomainPTB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)8626723
CommentsThe phosphotyrosine-binding (PTB) domain of human SHC-transforming protein 1 (SHC1) interacts with the tyrosine-phosphorylated NPxY motif of human Insulin receptor (INSR)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)