Instance ID10772
Regular Expression(x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y))
Motif InstanceSLDNPDY
Bait Uniprot AccessionP00533
Bait Uniprot IdentifierEGFR_HUMAN
Bait Gene NameEGFR
Bait OrganismHomo sapiens (Human)
Sequence Position1166-1172
Critical ResiduesP7
Motif PTM(s)Phosphorylation at Tyr-P7
Secondary StructureBeta turn
Experimental Method(s)Y2H; Mutation analysis; Pull down
Interaction ID20772
Interacting DomainPTB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15476828
CommentsPhosphotyrosine binding (PTB) domains of the Human adaptor protein DOK1 specifically associates with the tyrosine-phosphorylated NPxY motif (1166-1172) of human Epidermal growth factor receptor (EGFR)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)