Instance ID10773
Regular Expression(x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y))
Motif InstanceAFDNPDY
Bait Uniprot AccessionP21860
Bait Uniprot IdentifierERBB3_HUMAN
Bait Gene NameERBB3
Bait OrganismHomo sapiens (Human)
Sequence Position1322-1328
Critical ResiduesP7
Motif PTM(s)Phosphorylation at Tyr-P7
Secondary StructureBeta turn
Experimental Method(s)Co-IP; Protein kinase assay; Mutation analysis
Interaction ID20773
Interacting DomainPTB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)8026468
CommentsThe phosphotyrosine-binding (PTB) domain of human SHC-transforming protein 1 (SHC1) interacts with the tyrosine-phosphorylated NPxY motif of human Proto-oncogene-like protein c-ErbB-3 (ERBB3)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)