Instance ID10781
Regular Expression[LI]xCx[DE]
Motif InstanceLYCYE
Bait Uniprot AccessionP03129
Bait Uniprot IdentifierVE7_HPV16
Bait Gene NameE7
Bait OrganismHuman papillomavirus type 16
Sequence Position22-26
Critical ResiduesP1; P3; P5
Motif PTM(s)Unknown
Secondary StructureExtended conformation
Experimental Method(s)X-ray crystallography
Interaction ID20781
Interacting DomainB domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)9495340
CommentsThe Rb-binding LxCxE motif in the human papilloma virus E7 oncoprotein that mediates binding to a highly conserved shallow groove in the B domain of the human retinoblastoma protein (RB)

© 2014 Bose Institute, Kolkata. All rights reserved

For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)