Instance ID10791
Regular Expression[LI]xCx[DE]
Motif InstanceLFCFE
Bait Uniprot AccessionQ12931
Bait Uniprot IdentifierTRAP1_HUMAN
Bait Gene NameTRAP1
Bait OrganismHomo sapiens (Human)
Sequence Position525-529
Critical ResiduesP3
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Y2H
Interaction ID20791
Interacting DomainB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)8756626
CommentsThe Rb-binding LxCxE motif in the Human Heat shock protein HSP75/TRAP1 that mediates binding to the human retinoblastoma protein (RB) during mitosis and after heat shock, which suggests that HSP75 may act as a chaperone molecule to refold denatured RB into its native conformation

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)