Instance ID10792
Regular Expression[LI]xCx[DE]
Motif InstanceIRCDE
Bait Uniprot AccessionQ13029
Bait Uniprot IdentifierPRDM2_HUMAN
Bait Gene NamePRDM2
Bait OrganismHomo sapiens (Human)
Sequence Position310-314
Critical ResiduesP3
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Co-IP; Mutation analysis
Interaction ID20792
Interacting DomainB domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)7538672
CommentsThe Rb-binding LxCxE motif in the Human Zinc finger protein RIZ (PRDM2) that mediates binding to the human retinoblastoma protein (RB) suggesting a role for RIZ in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)