Instance ID10807
Regular Expressionxx[LIMV]xx[LM][FY]Dx
Motif InstanceEGIRDLFDC
Bait Uniprot AccessionQ01094
Bait Uniprot IdentifierE2F1_HUMAN
Bait Gene NameE2F1
Bait OrganismHomo sapiens (Human)
Sequence Position419-427
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Y2H; Pull down(GST tag); Competition binding
Interaction ID20807
Interacting DomainRb pocket AB groove
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)8346196, 8413249
CommentsHuman RB suppresses Transcription factor E2F1-mediated transcriptional activation through direct physical association via the LxxLFD retinoblastoma (RB)-binding sequence

© 2014 Bose Institute, Kolkata. All rights reserved

For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)