Instance ID10808
Regular Expressionxx[LIMV]xx[LM][FY]Dx
Motif InstanceEGISDLFDS
Bait Uniprot AccessionQ14209
Bait Uniprot IdentifierE2F2_HUMAN
Bait Gene NameE2F2
Bait OrganismHomo sapiens (Human)
Sequence Position420-428
Critical ResiduesP1; P2; P7
Motif PTM(s)Unknown
Secondary Structure3(10)-helix
Experimental Method(s)X-ray crystallography; Mutation analysis; ITC
Interaction ID20808
Interacting DomainRb pocket AB groove
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12502741
CommentsHuman RB suppresses Transcription factor E2F2-mediated transcriptional activation through direct physical association via the LxxLFD retinoblastoma (RB)-binding sequence

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)