Instance ID10809
Regular Expressionxx[LIMV]xx[LM][FY]Dx
Motif InstancePTLHELYDL
Bait Uniprot AccessionP03255
Bait Uniprot IdentifierE1A_ADE05
Bait Gene NameNot Available
Bait OrganismHuman adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5)
Sequence Position41-49
Critical ResiduesP3; P4; P7
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; ITC; Pull down(GST tag); X-ray crystallography
Interaction ID20809
Interacting DomainRb pocket AB groove
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)1534854, 17974914
CommentsThe LxxLFD retinoblastoma (RB)-binding sequence in the amino terminus of Human adenovirus Early E1A 32 kDa protein that mediates binding to the human retinoblastoma protein (RB)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)