Instance ID10820
Regular Expression[LIVMP]x{0,2}(T)Pxx([ST])
Motif InstancePGTPPSS
Bait Uniprot AccessionP13051
Bait Uniprot IdentifierUNG_HUMAN
Bait Gene NameUNG
Bait OrganismHomo sapiens (Human)
Sequence Position58-64
Critical ResiduesP3
Motif PTM(s)Phosphorylation at Thr-P3
Secondary StructureDisordered
Experimental Method(s)Mass spectrometry; Mutation analysis
Interaction ID20820
Interacting DomainWD40 repeat domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)18079698
CommentsThe TPxxS phospho-dependent degron in Human Uracil-DNA glycosylase (UNG) that binds the F box protein FBW7 (also called FBXW7, hCdc4 or hSel10) of the SCF complex via WD40 beta propeller for subsequent ubiquitin-mediated degradation

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)