Instance ID10821
Regular Expression[LIVMP]x{0,2}(T)Pxx([ST])
Motif InstanceLTPPPS
Bait Uniprot AccessionP36956
Bait Uniprot IdentifierSRBP1_HUMAN
Bait Gene NameSREBF1
Bait OrganismHomo sapiens (Human)
Sequence Position425-430
Critical ResiduesP2; P6
Motif PTM(s)Phosphorylation at Thr-P2 & Ser-P6
Secondary StructureUnknown
Experimental Method(s)Protein kinase assay; ChIP; Mutation analysis; Co-IP
Interaction ID20821
Interacting DomainWD40 repeat domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16825193, 16054087
CommentsThe TPxxS phospho-dependent degron in Human Sterol regulatory element-binding protein 1 (SREBF1) that serves as a recognition motif for the SCF(FBW7) ubiquitin ligase and enhances its ubiquitination and degradation in a manner dependent on the phosphorylation of T426 and S430

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)