Instance ID10822
Regular Expression[LIVMP]x{0,2}(T)Pxx([ST])
Motif InstanceLLTPPQS
Bait Uniprot AccessionP24864
Bait Uniprot IdentifierCCNE1_HUMAN
Bait Gene NameCCNE1
Bait OrganismHomo sapiens (Human)
Sequence Position393-399
Critical ResiduesP3; P7
Motif PTM(s)Phosphorylation at Thr-P3 & Ser-P7
Secondary StructureUnknown
Experimental Method(s)X-ray crystallography; ITC; Mutation analysis
Interaction ID20822
Interacting DomainWD40 repeat domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)17434132, 14536078
CommentsThe TPxxS phospho-dependent degron in Human G1/S-specific cyclin-E1 (CCNE1) that serves as a recognition motif for the SCF(FBW7) ubiquitin ligase, which mediates the degradation of cyclin E within catalytically active cyclin E-Cdk2 complexes and is not involved in the turnover of unbound or unphosphorylated cyclin E

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)