Instance ID10823
Regular Expression[LIVMP]x{0,2}(T)Pxx([ST])
Motif InstanceLLPTPPLS
Bait Uniprot AccessionP01106
Bait Uniprot IdentifierMYC_HUMAN
Bait Gene NameMYC
Bait OrganismHomo sapiens (Human)
Sequence Position55-62
Critical ResiduesP4; P8
Motif PTM(s)Phosphorylation at Thr-P4 & Ser-P8
Secondary StructureUnknown
Experimental Method(s)NMR; Competition binding; Co-IP; Ubiquitinase assay
Interaction ID20823
Interacting DomainWD40 repeat domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)15992821, 15103331
CommentsPhosphorylation-dependent degradation of Human c-Myc is mediated by the F-box protein F box protein FBXW7 of the SCF complex in a manner dependent on the phosphorylation of threonine-58 and serine-62

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)