Instance ID10824
Regular Expression[LIVMP]x{0,2}(T)Pxx([ST])
Motif InstancePGETPPLS
Bait Uniprot AccessionP05412
Bait Uniprot IdentifierJUN_HUMAN
Bait Gene NameJUN
Bait OrganismHomo sapiens (Human)
Sequence Position236-243
Critical ResiduesP8
Motif PTM(s)Phosphorylation at Ser-P8
Secondary StructureUnknown
Experimental Method(s)Peptide binding to perpetrator; Mutation disrupting interaction; Competition binding
Interaction ID20824
Interacting DomainWD40 repeat domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)16023596
CommentsPhosphorylation of Human c-Jun by GSK3 at Ser-243 creates a high-affinity binding site for the E3 ligase FBW7, which targets c-Jun for polyubiquitination and proteasomal degradation

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)