Instance ID10825
Regular Expression[LIVMP]x{0,2}(T)PxxE
Motif InstancePFLTPSPE
Bait Uniprot AccessionP46531
Bait Uniprot IdentifierNOTC1_HUMAN
Bait Gene NameNOTCH1
Bait OrganismHomo sapiens (Human)
Sequence Position2508-2515
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction
Interaction ID20825
Interacting DomainWD40 repeat domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11585921, 11461910
CommentsThe phospho-dependent degron in Human Neurogenic locus notch homolog protein 1 (NOTCH1) that binds the F-box/WD40 repeat protein FBW7 (also called FBXW7, hCdc4 or SEL-10), which leads to an increase in Notch signaling

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)