Instance ID10827
Regular Expressionxx[DE]x(T)PxK
Motif InstanceSVEQTPRK
Bait Uniprot AccessionP49918
Bait Uniprot IdentifierCDN1C_HUMAN
Bait Gene NameCDKN1C
Bait OrganismHomo sapiens (Human)
Sequence Position306-313
Critical ResiduesP5
Motif PTM(s)Phosphorylation at Thr-P5
Secondary StructureUnknown
Experimental Method(s)Ubiquitinase assay; Knock out; Co-IP; Alanine scanning
Interaction ID20827
Interacting DomainLeucine-rich repeats (LRR)
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12925736
CommentsThe phospho-dependent degron in Human Cyclin-dependent kinase inhibitor 1C or p57Kip2 (CDKN1C) is recognised by Human F-box/LRR-repeat protein SKP2, which is responsible for regulating the cellular level of p57Kip2 by targeting it for ubiquitylation and proteolysis

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)