Instance ID10829
Regular Expressionxx[DE]x(T)PxK
Motif InstanceSVEQTPKK
Bait Uniprot AccessionP46527
Bait Uniprot IdentifierCDN1B_HUMAN
Bait Gene NameCDKN1B
Bait OrganismHomo sapiens (Human)
Sequence Position183-190
Critical ResiduesP5
Motif PTM(s)Phosphorylation at Thr-P5
Secondary StructureUnknown
Experimental Method(s)Ubiquitinase assay; Mutation analysis; X-ray crystallography
Interaction ID20829
Interacting DomainLeucine-rich repeats (LRR)
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)16209941
CommentsThe phospho-dependent degron in Human Cyclin-dependent kinase inhibitor 1B or p27Kip1 (CDKN1B) is recognised by Human F-box/LRR-repeat protein SKP2 depending on Thr-187 phosphorylation and causing ubiquitin-mediated proteolysis of the Cdk2 inhibitor p27Kip1

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)