Instance ID10831
Regular ExpressionD(S)Gx{2,3}([ST])
Motif InstanceDSGIES
Bait Uniprot AccessionO00221
Bait Uniprot IdentifierIKBE_HUMAN
Bait Gene NameNFKBIE
Bait OrganismHomo sapiens (Human)
Sequence Position156-161
Critical ResiduesP2; P6
Motif PTM(s)Phosphorylation at Ser-P2 & Ser-P6
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Radiolabel; Co-IP
Interaction ID20831
Interacting DomainWD40 repeat domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10497169
CommentsThe DSGxxS phospho-dependent degron in human NF-kappa-B inhibitor epsilon (NFKBIE/IKBE) that binds the F-box/WD repeat-containing protein beta-TrCP (BTRC) of the SCF-betaTrCP1 complex leading to ubiquitination and degradation of IKBE

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)