Instance ID10832
Regular ExpressionD(S)Gx{2,3}([ST])
Motif InstanceDSGIHS
Bait Uniprot AccessionP35222
Bait Uniprot IdentifierCTNB1_HUMAN
Bait Gene NameCTNNB1
Bait OrganismHomo sapiens (Human)
Sequence Position32-37
Critical ResiduesP1; P2; P3; P6
Motif PTM(s)Phosphorylation at Ser-P2 & Ser-P6
Secondary StructureUnknown
Experimental Method(s)X-ray crystallography; Protein kinase assay
Interaction ID20832
Interacting DomainWD40 repeat domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)12820959
CommentsThe DSGxxS phospho-dependent degron present in human Beta-catenin (CTNNB1) that binds the F-box/WD repeat-containing protein beta-TrCP (BTRC), which recruits CTNNB1 to the SCF ubiquitin ligase complex

© 2014 Bose Institute, Kolkata. All rights reserved

For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)