Instance ID10833
Regular ExpressionD(S)Gx{2,3}([ST])
Motif InstanceDSGVETS
Bait Uniprot AccessionP19838
Bait Uniprot IdentifierNFKB1_HUMAN
Bait Gene NameNFKB1
Bait OrganismHomo sapiens (Human)
Sequence Position926-932
Critical ResiduesP2; P7
Motif PTM(s)Phosphorylation at Ser-P2 & Ser-P7
Secondary StructureUnknown
Experimental Method(s)Competition binding; Peptide binding to perpetrator; Protein kinase assay
Interaction ID20833
Interacting DomainWD40 repeat domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12482991
CommentsThe DSGxxS phospho-dependent degron present in human Nuclear factor NF-kappa-B p105 subunit (NFKB1) that binds to the F-box/WD repeat-containing protein beta-TrCP (BTRC) for beta-TrCP-mediated proteolysis of NF-kappaB1 p105

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)