Instance ID10834
Regular ExpressionD(S)Gx{2,3}([ST])
Motif InstanceDSGLDS
Bait Uniprot AccessionP25963
Bait Uniprot IdentifierIKBA_HUMAN
Bait Gene NameNFKBIA
Bait OrganismHomo sapiens (Human)
Sequence Position31-36
Critical ResiduesP2; P6
Motif PTM(s)Phosphorylation at Ser-P2 & Ser-P6
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Radiolabel; Mass spectrometry; Protein kinase assay; Peptide binding to perpetrator; Co-IP
Interaction ID20834
Interacting DomainWD40 repeat domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10497169, 10230406, 9990852
CommentsThe DSGxxS phospho-dependent degron in human NF-kappa-B inhibitor alpha (NFKBIA/IKBA) that binds to the F-box/WD repeat-containing protein beta-TrCP (BTRC), which recruits IKBA to the SCF ubiquitin ligase complex leading to its ubiquitination and degradation

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)