Instance ID10835
Regular ExpressionD(S)Gx{2,3}([ST])
Motif InstanceDSGQGS
Bait Uniprot AccessionQ9HAW4
Bait Uniprot IdentifierCLSPN_HUMAN
Bait Gene NameCLSPN
Bait OrganismHomo sapiens (Human)
Sequence Position29-34
Critical ResiduesP2; P6
Motif PTM(s)Phosphorylation at Ser-P2 & Ser-P6
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Co-IP; Fluorescence-activated cell sorting
Interaction ID20835
Interacting DomainWD40 repeat domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16885022
CommentsThe DSGxxS phospho-dependent degron in Human Claspin (CLSPN) that binds to the F-box/WD repeat-containing protein beta-TrCP (BTRC) for SCF-betaTrCP complex-mediated degradation of Claspin, which regulates recovery from the DNA replication checkpoint response

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)