Instance ID10836
Regular ExpressionD(S)Gx{2,3}([ST])
Motif InstanceDSGICMS
Bait Uniprot AccessionP18848
Bait Uniprot IdentifierATF4_HUMAN
Bait Gene NameATF4
Bait OrganismHomo sapiens (Human)
Sequence Position218-224
Critical ResiduesP1; P2
Motif PTM(s)Phosphorylation at Ser-P2 & Ser-P7
Secondary StructureUnknown
Experimental Method(s)Y2H; Mutation analysis; Radiolabel; Protein kinase assay
Interaction ID20836
Interacting DomainWD40 repeat domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11238952
CommentsDegradation of human cAMP-dependent transcription factor ATF4 relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase via the DSGxxS phospho-dependent degron

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)