Instance ID10837
Regular ExpressionD(S)Gx{2,3}([ST])
Motif InstanceDSGLPS
Bait Uniprot AccessionQ12959
Bait Uniprot IdentifierDLG1_HUMAN
Bait Gene NameDLG1
Bait OrganismHomo sapiens (Human)
Sequence Position597-602
Critical ResiduesP2; P6
Motif PTM(s)Phosphorylation at Ser-P2 & Ser-P6
Secondary StructureUnknown
Experimental Method(s)Pull down; Western blot; Co-IP; RNA interference
Interaction ID20837
Interacting DomainWD40 repeat domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)12902344
CommentsThe DSGxxS phospho-dependent degron present in human Disks large homolog 1 (DLG1) that mediates phosphorylation-dependent interaction with the beta-TrCP ubiquitin ligase receptor

© 2014 Bose Institute, Kolkata. All rights reserved

For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)